Oral biologics delivery is an innovative approach aimed at replacing injections for large therapeutic molecules like peptides, proteins, and RNA. This system uses PH20 hyaluronidase to temporarily enhance intestinal permeability, allowing drugs to pass into the bloodstream when released in the gut via enteric-coated capsules. Advanced formulations ensure stability, high drug-loading, and >10% bioavailability. Key applications include oral insulin, antibodies, and enzyme replacement therapies. This method offers a patient-friendly, needle-free alternative for chronic disease management and could reshape how biologics are delivered in endocrinology, oncology, and infectious diseases.
