Needle-less drug delivery systems are emerging as a patient-friendly alternative to conventional injections, minimizing pain, fear, and infection risk. Technologies include jet injectors, micro-needle patches, transdermal patches, nasal sprays, inhalers, and oral dissolvable films. These systems improve compliance in vaccination programs, chronic disease management, and pediatric care. Innovations like wireless-controlled patches and iontophoresis are expanding therapeutic applications to proteins, vaccines, and biologics. The market potential is bolstered by demand for at-home healthcare, portability, and the push toward self-administered therapies .